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2018 / 3 月份 演講
演講題目 Structural insight into activation of HECT E3 ligase: implications to human diseases
時間 年/月/日 2018/3/6 11:00 ~ 12:00
地點 生化所114室
主講人 吳昆峯博士
主講人背景 本所客座助理教授
演講主持人 蔡明道院士
洽詢人員 劉小姐
洽詢電話 02-27855696#1165
洽詢信箱 liukchun@gate.sinica.edu.tw
演講摘要 Ubiquitination is one of the important protein post-translational modifications in eukaryotic systems affecting proteins in many ways such as protein degradation via the proteasome, alter localization in the cell, or change protein-protein interactions in signaling pathways. The ubiquitination is carried out by 3 cascading enzymes termed E1, E2 and E3 where E3, the ligase, modifies ubiquitin molecules to target proteins. HECT-family E3 ligases are one kind of E3 ligases in human genome (28 members) controlling virtually every cellular process and are misregulated in numerous diseases. Understanding activation of HECT E3 is limited by the availability of potent modulators selectively against individual family members. I will present a system-wide toolkit named ubiquitin variants (UbVs) that significantly inhibit or activate HECT E3 ligases in distinct regulation mechanisms. Structural analysis of 7 HECT-UbV complexes reveal details of activation or inhibition mechanisms where inhibitor UbVs directly hijack the E2 binding site and activator UbVs promote substrate ubiquitinations by occupying the ubiquitin-binding exosite at HECT E3 catalytic domain. Effectively regulation of NEDD4-subfamily HECT E3 ligases in cells and intestinal organoids demonstrates that UbVs are potential therapeutics for many HECT-linked diseases including neurodegenerative Parkinson’s disease, cancers and viral infections.-Dr. Kuen-Phon Wu
 
演講題目 The power and beauty of single particle cryo-EM
時間 年/月/日 2018/3/20 11:00 ~ 12:00
地點 生化所114室
主講人 Dr. Matthias Wolf
主講人背景 日本沖繩科學技術大學院大學分子低溫電顯單位助教授
演講主持人 徐尚德副研究員
洽詢人員 劉小姐
洽詢電話 02-27855696#1165
洽詢信箱 liukchun@gate.sinica.edu.tw
 
演講題目 Making new connection between TORC1, autophagy, and metabolism
時間 年/月/日 2018/3/21 11:00 ~ 12:00
地點 生化所114室
主講人 Dr. Hong-Wen Tang
主講人背景 美國哈佛醫學院遺傳學所博士後研究
演講主持人 陳光超副研究員
洽詢人員 劉小姐
洽詢電話 02-27855696#1165
洽詢信箱 liukchun@gate.sinica.edu.tw
 

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