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2018 / 12 月份 演講
演講題目 Dynamics and Mechanisms of DNA Repair by Photolyases
時間 年/月/日 2018/12/21 11:00 ~ 12:00
地點 生化所114室
主講人 Dr. Dongping Zhong
主講人背景 美國俄亥俄州立大學物理研究所、化學與生化研究所教授
演講主持人 蔡明道特聘研究員
洽詢人員 劉小姐
洽詢電話 02-27855696#1165
洽詢信箱 liukchun@gate.sinica.edu.tw
演講摘要 Photolyase is a photoenzyme using blue light to repair UV-induced DNA lesions in three life kingdoms. Although earlier studies on microbial photolyases revealed a critical electron-tunneling pathway for the repair mechanism, it is unknown if such electron superexchange can also operate in distant eukaryotic photolyases. Here, using femtosecond spectroscopy we show our systematic dissection of the repair process with seven electron-transfer reactions among ten elementary steps on various photolyases in all life branches. We found a new, unified electron-transfer strategy for all photolyases with bifurcated routes through a conserved structural configuration. Both pathways are operative in repair depending on the relative reduction potentials and converged at damaged-DNA site for efficient repair. From lower microbes to higher eukaryotes, the electron exploits from mainly direct tunneling along one route to dominant two-step hopping on the other path with the same conserved active-site structure through evolution.-Dr. Dongping Zhong
 

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