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研討會公告              ● 生化所行事曆

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2018/11 月份 演講
演講題目 Tangling with Alzheimer's disease - discovering therapeutics and risk factors
時間 年/月/日 2018/11/1 11:00 ~ 12:00
地點 生化所114室
主講人 Dr. Min-Hao Kuo
主講人背景 美國密西根州立大學生物與分子生物學研究所副教授
演講主持人 陳佩燁研究員
洽詢人員 劉小姐
洽詢電話 02-27855696#1165
洽詢信箱 liukchun@gate.sinica.edu.tw
 
演講題目 DNA repair studies using lesion-containing oligonucleotides
時間 年/月/日 2018/11/5 11:00 ~ 12:00
地點 生化所114室
主講人 Dr. Junpei Yamamoto
主講人背景 日本大阪大學材料工程科學研究所副教授
演講主持人 蔡明道特聘研究員
洽詢人員 劉小姐
洽詢電話 02-27855696#1165
洽詢信箱 liukchun@gate.sinica.edu.tw
演講摘要 DNA is spontaneously damaged by endogenous and exogenous factors such as reactive oxygen species, ultraviolet, ionizing radiations, metabolites of chemical substances, drugs, and so on, resulting in alteration of chemical structures of DNA. Such DNA damage is repaired by several specific DNA repair pathways, depending on the type of the lesions. For the in vitro biochemical studies, oligonucleotides containing DNA damage are indispensable. Chemical synthesis of oligonucleotides containing DNA damage is a powerful strategy that can provide a uniform, structure- and position-defined substrates without limitation of DNA lengths (up to ~100 nt) and sequence. In this talk, I would like to introduce our works on solid-phase synthesis of oligonucleotides containing UV-damaged DNA, i.e. cyclobutane pyrimidine dimers and pyrimidine(6–4)pyrimidone photoproducts (and its Dewar valence isomer), and its application to DNA repair by a Y-family polymerase and photolyases.-Dr. Junpei Yamamoto
 
演講題目 Molecular dynamics simulations of aggregates of amyloid-β peptides
時間 年/月/日 2018/11/20 11:00 ~ 12:00
地點 生化所114室
主講人 Dr. Hisashi Okumura
主講人背景 日本自然科學研究機構分子科學研究所副教授
演講主持人 陳佩燁研究員
洽詢人員 劉小姐
洽詢電話 02-27855696#1165
洽詢信箱 liukchun@gate.sinica.edu.tw
演講摘要 Amyloids are insoluble and misfolded fibrous protein aggregates and associated with more than 40 serious human diseases. For example, amyloid-β peptides (Aβ) form amyloid fibrils that are associated with Alzheimer's disease. To investigate the oligomerization process of Aβ, we developed Hamiltonian replica-permutation molecular dynamics (MD) method and applied this method to Aβ in explicit water solvent [1, 2, 3, 4]. We will show the oligomerization process of Aβ. We also performed MD simulations of Aβ fibrils in explicit water. We discovered that molecular structure is different between two ends: The two β-sheets β1 and β2 are close to each other at the even end. On the other hand, at the odd end the Aβ fluctuates more and takes an open form, too [5]. Our theoretical prediction was proved by experiment after our MD simulations. We further performed nonequilibrium MD simulations with sinusoidal pressure and visualized this process with movies to describe the disruption of amyloid-β fibrils by ultrasonic cavitation. When the pressure is negative, a bubble was formed. When the pressure became positive, the bubble collapsed, and water molecules crashed against the hydrophilic residues to disrupt the amyloid [6].-Dr. Hisashi Okumura Reference 1.S. G. Itoh and H. Okumura, J. Comput. Chem. (2013) 34 2493. 2.S. G. Itoh and H. Okumura, J. Phys. Chem. B (2014) 118 11428. 3.S. G. Itoh and H. Okumura, J. Chem. Theory Comput. (2013) 9 570. 4.S. G. Itoh and H. Okumura, J. Phys. Chem. B (2016) 120 6555. 5.H. Okumura and S. G. Itoh, Sci. Rep. 6 (2016) 38422 (9 pages). 6.H. Okumura and S. G. Itoh, J. Am. Chem. Soc. 136 (2014) 10549-10552.
 
演講題目 Bacterial lipid trafficking and outer membrane homeostasis
時間 年/月/日 2018/11/22 11:00 ~ 12:00
地點 生化所114室
主講人 Dr. Shu Sin Chng
主講人背景 新加坡國立大學化學研究所副教授
演講主持人 史有伶副研究員
洽詢人員 劉小姐
洽詢電話 02-27855696#1165
洽詢信箱 liukchun@gate.sinica.edu.tw
演講摘要 Diderm bacteria, such as Gram-negative bacteria and mycobacteria, contain two lipid bilayers in their cellular envelopes – an inner membrane (IM) comprising mostly of phospholipids (PLs), and an outer membrane (OM) that additionally contains unique glycolipids (lipopolysaccharides (LPS) in Gram-negative bacteria and mycolic acids in mycobacteria). The OM is essential for growth in these organisms. Furthermore, the OM serves as an effective permeability barrier that in part allows Gram-negative bacteria and mycobacteria to survive in harsh environments, and renders them intrinsically resistant to many antibiotics. Despite the importance of the OMs in these bacteria, the processes that assemble these bilayers, in particular lipid transport, are not well understood. In this seminar, I will describe our work in understanding and characterizing lipid trafficking pathways in Escherichia coli and Mycobacterium smegmatis, and discuss how these systems function in maintaining lipid homeostasis in the OMs of these organisms.-Dr. Shu Sin Chng
 
演講題目 Isoform-dependent regulation of endocytic trafficking, signaling and migration
時間 年/月/日 2018/11/29 11:00 ~ 12:00
地點 生化所114室
主講人 陳炳宏博士
主講人背景 國立臺灣大學醫學院生物化學暨分子生物學研究所助教授
演講主持人 陳光超副研究員
洽詢人員 劉小姐
洽詢電話 02-27855696#1165
洽詢信箱 liukchun@gate.sinica.edu.tw
 

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