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研討會公告              ● 生化所行事曆

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2018/2 月份 演講
演講題目 Cell Sheet Technology and Potential Drugs for Articular Cartilage Regeneration
時間 年/月/日 2018/2/2 10:30 ~ 12:00
地點 生化所114室
主講人 Dr. Masato Sato
主講人背景 日本東海大學醫學院骨科所教授
演講主持人 王惠鈞院士
洽詢人員 王博士
洽詢電話 02-27855596#4010
洽詢信箱 ncwang@gate.sinica.edu.tw
 
演講題目 CryoEM studies of pre-mRNA splicing reveal assembly and activation of the spliceosome
時間 年/月/日 2018/2/27 11:00 ~ 12:00
地點 生化所114室
主講人 Dr. Pei-Chun Lin
主講人背景 英國劍橋分子生物學實驗室研究員
演講主持人 蔡明道院士
洽詢人員 劉小姐
洽詢電話 02-27855696#1165
洽詢信箱 liukchun@gate.sinica.edu.tw
演講摘要 Intron removal requires recognition of exon-intron boundaries, stepwise assembly of the spliceosome from five small nuclear ribonucleoprotein particles (snRNPs; U1, U2, U4, U5, U6) and extensive remodelling to form the spliceosome's catalytic center. In the beginning of pre-mRNA splicing, the intron 5'-splice site (5'SS) and the branch point (BP) sequence are selected and brought into the prespliceosome by the U1 and U2 snRNPs. The U4/U6.U5 tri-snRNP subsequently joins the prespliceosome to form the complete pre-catalytic spliceosome, which later converts to the catalytic active spliceosome. In my talk, I will report cryo-electron microscopy structures of the assembling yeast spliceosome. The data reveal important regulatory splicing intermediates and provide crucial insights into the mechanism of spliceosome activation.-Dr. Pei-Chun Lin
 

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