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黃開發 博士
研究技師
中央研究院生物化學研究所 309室
臺北市南港區115研究院路二段128號
TEL: +886-2-2785-5696 ext. 3090
FAX: +886-2-2788-9759
huangkf@gate.sinica.edu.tw

專長

蛋白質X-光結晶學 / 同步輻射X-光繞射數據收集 / 結構生物學 / 以蛋白質結構為基礎的藥物最佳化 / 以結構為基礎的蛋白質分析

研究

以蛋白質結構為基礎的小分子藥物開發、設計及最佳化,以治療神經退化性疾病

2002,10 - 2006,01 博士, 生化科學研究所, 國立臺灣大學
1991,10 - 1993,06 碩士, 生化科學研究所, 國立臺灣大學
1986,09 - 1991,06 學士, 獸醫學系, 國立中興大學

2017,02 - 研究技師, 中研院生化所
2016,01 - 計畫總經理, 台灣蛋白質計畫
2013,01 - 2017,02 研究副技師, 中研院生化所
2011,05 - 2015,12 計畫經理, 國家蛋白質結構分析核心設施
2009,01 - 2012,12 研究助技師, 中研院生化所
2005,10 - 2011,04 計畫經理, 國家蛋白質生產及X-光結晶學核心設施
1993,08 - 2009,01 研究助理, 中研院生化所

    論文列表
Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumannii by bacteriophage ΦAB6 tailspike protein.
Lee, I.-M., Tu, I.-F., Yang, F.-L., Ko, T.-P., Liao, J.-H., Lin, N.-T., Wu, C.-Y., Ren, C.-T., Wang, A. H.-J., Chang, C.-M., Huang, K.-F. & Wu, S.-H. Scientific Reports (2017)
A multivalent marine lectin from Crenomytilus grayanus possesses anti-cancer activity through recognizing globotriose Gb3.
Liao, J.-H., Chien, C.-T., Wu, H.-Y., Huang, K.-F., Wang, I., Ho, M.-R., Tu, I.-F., Lee, I.-M., Li, W., Shih, Y.-L., Wu, C.-Y., Lukyanov, P.-A., Hsu, S.-T. & Wu, S.-H. Journal of the American Chemical Society (2016)
Avenaciolides: potential MurA-targeted inhibitors against peptidoglycan biosynthesis in methicillin-resistant Staphylococcus aureus (MRSA).
Chang, C.-M., Chern, J., Chen, M.-Y., Huang, K.-F., Chen, C.-H., Yang, Y.-L. & Wu, S.-H. Journal of the American Chemical Society (2015)
Linked production of pyroglutamate-modified proteins via self-cleavage of fusion tags with TEV protease and autonomous N-terminal cyclization with glutaminyl cyclase in vivo.
Shih, Y.-P., Chou, C.-C., Chen, Y.-L., Huang, K.-F. & Wang, A. H.-J. PLoS One (2014)
Structural and functional analyses of a glutaminyl cyclase from Ixodes scapularis reveal metal-independent catalysis and inhibitor binding.
Huang, K.-F., Hsu, H.-L., Karim, S. & Wang, A. H.-J. Acta Crystallographica Section D Biological Crystallography (2014)
Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding.
Huang, K.-F., Liaw, S.-S., Huang, W.-L., Chia, C.-Y., Lo, Y.-C., Chen, Y.-L. & Wang, A. H.-J. Journal of Biological Chemistry (2011)
Crystal Structure and Functional Analysis of the Glutaminyl Cyclase from Xanthomonas campestris. (Featured on Cover)
Huang, W.-L., Wang, Y.-R., Ko, T.-P., Chia, C.-Y., Huang, K.-F. & Wang, A. H.-J. Journal of Molecular Biology (2010)
A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Huang, K.-F., Wang, Y.-R., Chang, E.-C., Chou, T.-L. & Wang, A. H.-J. The Biochemical journal (2008)
Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation.
Huang, K.-F., Liu, Y.-L., Cheng, W.-J., Ko, T.-P. & Wang, A. H.-J. Proceedings of the National Academy of Sciences of the United States of America (2005)
Crystal structure of a platelet-agglutinating factor isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus). (Featured on Cover)
Huang, K.-F., Ko, T.-P., Hung, C.-C., Chu, J., Wang, A. H.-J. & Chiou, S.-H. The Biochemical Journal (2004)

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