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Dr. Ming-Daw Tsai
Distinguished Research Fellow
Room 316, Institute of Biological Chemistry, Academia Sinica
128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan
TEL: +886-2-2785-5696 ext. 3070
FAX: +886-2-2788-9759
Ming-Daw Tsai's Website

The main research program of Tsai lab focuses on proteins involved in cell cycle progression that are closely related with cancer and virus infection. Our structure and function studies on INK, CDK4, and Chk2 proteins shed great light on the mechanisms underlying some cancer diseases, while our enzymological characterizations of human and viral polymerases empower us to further understand the DNA damage response and repair at DNA level. In addition, we investigate the signaling pathways involving protein-phosphoprotein interactions mediated by the FHA domain, in both human (e.g. Ki67) and yeast (e.g. Rad53 and Dun1). Another project focuses on the mechanism and biological function of histone demethylases, including yeast Rph1 and human RBP2.

- 1978 Ph.D, Biochemistry & Medicinal Chemistry, Purdue University
- 1972 B.S., Chemistry, National Taiwan University, Taipei

2008,08 - present Distinguished Research Fellow, Institute of Biological Chemistry, Academia Sinica
2005 - present Director, Division of Functional Genomics, Genomics Research Center
2003 - present Director, National Research Program for Genomic Medicine Core Facility Office
1981 - present Kimberly Professor of Chemistry and Professor of Biochemistry, The Ohio State University (starting as Assistant Professor)
2008,08 - 2014,08 Director, Institute of Biological Chemistry, Academia Sinica
2006,10 - 2008,08 Acting Director, Institute of Biological Chemistry, Academia Sinica
1995 - 2003 Director, Chemistry/Biology Interface Training Program, OSU
1993 - 2007 Director, Office of Research Campus Chemical Instrument Center, The Ohio State University
1992 - 1992 Elected Fellow, American Association for the Advancement of Science (AAAS)
1992 - 1992 Distinguished Scholar Award, Ohio State University
1985 - 1990 Camille and Henry Dreyfus Teacher-Scholar
1985 - 1985 Faculty Research Award, Ohio State Chapter of Sigma Xi
1983 - 1985 Alfred P. Sloan Fellow

    Publications List
E339…R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors.
Yu-Fang Shen, Yu-Hou Chen, Shao-Ying Chu, Meng-I Lin, Hua-Ting Hsu, Pei-Yu Wu, Chao-Jung Wu, Hui-Wen Liu, Fu-Yang Lin, Gialih Lin, Pang-Hung Hsu, An-Suei Yang, Yih-Shyun E. Cheng, Ying-Ta Wu, Chi-Huey Wong*, Ming-Daw Tsai* Proceedings of the National Academy of Sciences of the United States of America (2011)
The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif.
Shengjiang Tu, Yu-Ching Teng, Chunhua Yuan, Ying-Ta Wu, Meng-Yu Chan, An-Ning Cheng, Po-Hsun Lin, Li-Jung Juan*, Ming-Daw Tsai* NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade.
H. Lee, C. Yuan, A. Hammet, A. Mahajan, S. W. Chen, M. R. Wu, M. I. Su, J. Heierhorst*, M. D. Tsai* Mol. Cell (2008)
Structure and Function of the Phosphothreonine-Specific FHA Domain.
Anjali Mahajan, Chunhua Yuan, Hyun Lee, Eric S.-W. Chen, Pei-Yu Wu, Ming-Daw Tsai* Science Signaling (2008)
Mechanistic comparison of high-fidelity and error-prone DNA polymerases and ligases involved in DNA repair.
Showalter AK, Lamarche BJ, Bakhtina M, Su MI, Tang KH, Tsai MD Chemical reviews (2006)
Sequential Phosphorylation and Multisite Interactions Characterize Specific Target Recognition by the FHA Domain of Ki-67.
In-Ja L. Byeon, Hongyuan Li, Haiyan Song, Angela M. Gronenborn, and Ming-Daw Tsai Nature Structural and Molecular Biology (2005)
Solution structure of a viral DNA polymerase X and evidence for a mutagenic function.
A. K. Showalter, I. J. Byeon, M. I. Su and M. D. Tsai Nat Struct Biol (2001)
Interfacial enzymology: the secreted phospholipase A(2)-paradigm.
O. G. Berg, M. H. Gelb, M. D. Tsai and M. K. Jain Chem Rev (2001)
Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4.
I. J. Byeon, J. Li, K. Ericson, T. L. Selby, A. Tevelev, H. J. Kim, P. O'Maille and M. D. Tsai Mol Cell (1998)

Updated 2014.02.14

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