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Dr. Chi-Huey  Wong
Joint Appointment Distinguished Research Fellow & President of Academia Sinica
Institute of Biological Chemistry, Academia Sinica
128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan
TEL: +886-2-2789-9400
FAX: +886-2-2785-3852
Chi-Huey Wong's Website

Chemical Biology and Drug Discovery

Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of both synthetic and bioorganic strategies is paramount to our research. Programmable one-pot reactions and enzymatic synthesis methods are being developed for the synthesis of complex oligosaccharides, homogeneous glycoproteins and glycoarrays. These tools and methods are used to understand the role of glycosylation in virology and to develop new carbohydrate-based medicines.

1979 - 1982 Ph.D, Chemistry, Massachusetts Institute of Technology

2006 - present President, Academia Sinica, Taipei, Taiwan
2003 - 2006 Director, The Genomic Research Center, Acadmia Sinica, Taipei, Taiwan
1991 - 1999 Head, Frontier Research Program on Glycotechnolgy, Institute of Physical and Chemical Research (RIKEN), Japan
1989 - 2006 Professor and Ernest W. Hahn Chair in Chemistry, The ScripScripps Research Institute
1983 - 1989 Assistant Professor through Professor of Chemistry and Biochemistry, Texas A&M University
1982 - 1983 Postdoctoral Fellow, Harvard University

    Publications List
A Common Glycan Structure on Immunoglobulin G for Enhancement of Effector Functions.
Lin CW, Tsai MH, Li ST, Tsai TI, Chu KC, Liu YC, Lai MY, Wu CY, Tseng YC, Shivatare SS, Wang CH, Chao P, Wang SY, Shih HW, Zeng YF, You TH, Liao JY, Tu YC, Lin YS, Chuang HY, Chen CL, Tsai CS, Huang CC, Lin NH, Ma C, Wu CY, and Wong CH. Proc. Nat. Acad. Sci. U.S.A. (2015)
Modular Synthesis of N-glycans and Arrays for the Hetero-ligand Binding Analysis of HIV Antibodies.
Shivatare S S, Chang SH, Tsai TI, Tseng SY, Lin YS, Cheng YY, Ren Pawar CT, S, Tsai CS, Shi HW, Zeng YF, Liang CH, Kwong PD, Burton DR, Wu CY and Wong CH. Nature Chemistry (2015)
An Azido-BODIPY Probe for Glycosylation: Initiation of Strong Fluorescence Upon Triazole Formation.
Shie JJ, Liu YC, Lee YM, Lim C, Fang JM, Wong CH. J. Am. Chem. Soc. (2014)
Vaccination of Monoglycosylated Hemagglutinin Induces Cross-Strain Protection against Influenza Virus Infections.
Chen JR, Yu YH, Tseng YC, Chiang WL, Chiang MF, Ko YA, Chiu YK, Ma SH, Wu CY, Jan JT, Lin KI, Ma C. and Wong CH. Proc. Nat. Acad. Sci. U.S.A. (2014)
Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer.
Huang YL, Hung JT, Cheung SKC, Lee HY, Chu KC, Li ST, Lin YC, Ren CT, Cheng TJR, Hsu TL, Yu AL, Wu CY, Wong CH. Proc. Natl. Acad. Sci. U.S.A. (2013)
Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog and elucidation of the mechanism of peptidoglycan synthesis.
Huang CY, Shih HW, Lin LY, Tien YW, Cheng TJR, Cheng WC, Wong CH, and Ma C. Proc. Nat. Acad. Sci. U.S.A. (2012)
Enzymes in the Synthesis of Glycoconjugates.
Schmaltz, R.; Hanson, S.R.; Wong, C.H. Chemical Reviews (2011)
Toward Automatic Oligosaccharide Synthesis and Applications.
Hsu, C.H.; Hung, S.C.; Wu, C.Y.; Wong, C.H. Angew. Chem. Int. Ed. (2011)
Enzymes for chemical synthesis.
Koeller KM, Wong CH. Nature (2001)
Toward automated synthesis of oligosaccharides and glycoproteins.
Sears P, Wong CH. Science (2001)

Updated 2017.03.08

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