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Dr. Chi-Huey Wong
Joint Appointment Distinguished Research Fellow & President of Academia Sinica
Institute of Biological Chemistry, Academia Sinica
128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan
TEL: +886-2-2789-9400
FAX: +886-2-2785-3852
chwong@gate.sinica.edu.tw
Chi-Huey Wong's Website


Chemical Biology and Drug Discovery

Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of small molecules targeting proteins and RNA has been performed to investigate how small molecules interact with biologically important molecules and in turn, learn more about the function of those molecules. Development of both synthetic and bioorganic strategies is also paramount to our research. Programmable one-pot reactions are being developed for the synthesis of complex oligosaccharides and glycoarrays and compliment new chemo-enzymatic strategies for the assembly of glycoproteins and other biologically active molecules.

- 1982 Ph.D, Chemistry, Massachusetts Institute of Technology

2006 - present Professor of Chemistry, The Scripps Research Institute
2006 - present President, Academia Sinica, Taipei, Taiwan
2006 - present Distinguished Professor of Chemistry and Biochemical Sciences, National Taiwan University
2003 - 2006 Director, The Genomic Research Center, Acadmia Sinica, Taipei, Taiwan
1996 - 2006 Member, The Skaggs Institute for Chemical Biology, The Scripps Research Institute
1991 - 1999 Head, Frontier Research Program on Glycotechnolgy, Institute of Physical and Chemical Research (RIKEN), Japan
1989 - 2006 Professor and Ernest W. Hahn Chair in Chemistry, The ScripScripps Research Institute
1983 - 1989 Assistant Professor through Professor of Chemistry and Biochemistry, Texas A&M University
1982 - 1983 Postdoctoral Fellow, Harvard University

    Publications List
Effects of neighboring glycans on antibody-carbohydrate interaction.
Liang CH, Wang SK, Lin CW, Wang CC, Wong CH, Wu CY. Angew. Chem. Int. Ed. (2011)
Enzymes in the Synthesis of Glycoconjugates.
Schmaltz, R.; Hanson, S.R.; Wong, C.H. Chemical Reviews (2011)
Efficient and Stereoselective Synthesis of α(2→9) Oligosialic Acids: From Monomers to Dodecamers.
Chu, K.C.; Ren, C.T.; Lu, C.P.; Hsu, C.H.; Sun, T.H.; Chao, T.A.; Lin, Y.F.; Wu, S.H.; Wong, C.H.; Wu, C.Y. Angew. Chem. Int. Ed. (2011)
Toward Automatic Oligosaccharide Synthesis and Applications.
Hsu, C.H.; Hung, S.C.; Wu, C.Y.; Wong, C.H. Angew. Chem. Int. Ed. (2011)
Differential receptor binding affinities of influenza hemagglutinins on glycan arrays.
Liao, H.Y.; Hsu, C.H.; Wang, S.C.; Liang, C.H.; Yen, H.Y.; Su, C.Y.; Jan, J.T.; Ren, C.T.; Cheng, T.J.; Wu, C.Y.; Wong, C.H. J. Am. Chem. Soc. (2010)
The Core Trisaccharide of an N-linked Glycoprotein Intrinsically Accelerates Folding and Enhances Stability.
Hanson SR, Culyba EK, Hsu TL, Wong CH, Kelly JW, Powers ET Proc Natl Acad Sci U S A. (2009)
Glycans on influenza hemagglutinin affect receptor binding and immune response.
Wang, C.C.; Chen, J.R.; Tseng, Y.C.; Hsu, C.H.; Hung, Y.F.; Chen, S.W.; Chen, C.M.; Khoo, K.H.; Cheng, T.J.; Cheng, Y.S.E.; Jan, J.T.; Wu, C.Y.; Ma, C.; Wong, C.H. Proc. Nat. Acad. Sci. U.S.A. (2009)
Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells.
Hsu TL, Hanson SR, Kishikawa K, Wang SK, Sawa M, Wong CH Proc Natl Acad Sci U S A. (2007)
Sugar-assisted ligation in glycoprotein synthesis.
Yang YY, Ficht S, Brik A, Wong CH J Am Chem Soc. (2007)
Sugar-Assisted Glycopeptide Ligation.
Brik A, Yang YY, Ficht S, Wong CH J Am Chem Soc. (2006)

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