::::中研院生化所 ::::

Chi-Huey Wong's Website

Chemical Biology and Drug Discovery

Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of small molecules targeting proteins and RNA has been performed to investigate how small molecules interact with biologically important molecules and in turn, learn more about the function of those molecules. Development of both synthetic and bioorganic strategies is also paramount to our research. Programmable one-pot reactions are being developed for the synthesis of complex oligosaccharides and glycoarrays and compliment new chemo-enzymatic strategies for the assembly of glycoproteins and other biologically active molecules.

- 1982

Ph.D, Chemistry, Massachusetts Institute of Technology

2006 - present	Professor of Chemistry, The Scripps Research Institute
2006 - present	President, Academia Sinica, Taipei, Taiwan
2006 - present	Distinguished Professor of Chemistry and Biochemical Sciences, National Taiwan University
2003 - 2006	Director, The Genomic Research Center, Acadmia Sinica, Taipei, Taiwan
1996 - 2006	Member, The Skaggs Institute for Chemical Biology, The Scripps Research Institute
1991 - 1999	Head, Frontier Research Program on Glycotechnolgy, Institute of Physical and Chemical Research (RIKEN), Japan
1989 - 2006	Professor and Ernest W. Hahn Chair in Chemistry, The ScripScripps Research Institute
1983 - 1989	Assistant Professor through Professor of Chemistry and Biochemistry, Texas A&M University
1982 - 1983	Postdoctoral Fellow, Harvard University

Effects of neighboring glycans on antibody-carbohydrate interaction.

Liang CH, Wang SK, Lin CW, Wang CC, Wong CH, Wu CY. Angew. Chem. Int. Ed. (2011)

Enzymes in the Synthesis of Glycoconjugates.

Schmaltz, R.; Hanson, S.R.; Wong, C.H. Chemical Reviews (2011)

Efficient and Stereoselective Synthesis of α(2→9) Oligosialic Acids: From Monomers to Dodecamers.

Chu, K.C.; Ren, C.T.; Lu, C.P.; Hsu, C.H.; Sun, T.H.; Chao, T.A.; Lin, Y.F.; Wu, S.H.; Wong, C.H.; Wu, C.Y. Angew. Chem. Int. Ed. (2011)

Toward Automatic Oligosaccharide Synthesis and Applications.

Hsu, C.H.; Hung, S.C.; Wu, C.Y.; Wong, C.H. Angew. Chem. Int. Ed. (2011)

Differential receptor binding affinities of influenza hemagglutinins on glycan arrays.

Liao, H.Y.; Hsu, C.H.; Wang, S.C.; Liang, C.H.; Yen, H.Y.; Su, C.Y.; Jan, J.T.; Ren, C.T.; Cheng, T.J.; Wu, C.Y.; Wong, C.H. J. Am. Chem. Soc. (2010)

The Core Trisaccharide of an N-linked Glycoprotein Intrinsically Accelerates Folding and Enhances Stability.

Hanson SR, Culyba EK, Hsu TL, Wong CH, Kelly JW, Powers ET Proc Natl Acad Sci U S A. (2009)

Glycans on influenza hemagglutinin affect receptor binding and immune response.

Wang, C.C.; Chen, J.R.; Tseng, Y.C.; Hsu, C.H.; Hung, Y.F.; Chen, S.W.; Chen, C.M.; Khoo, K.H.; Cheng, T.J.; Cheng, Y.S.E.; Jan, J.T.; Wu, C.Y.; Ma, C.; Wong, C.H. Proc. Nat. Acad. Sci. U.S.A. (2009)

Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells.

Hsu TL, Hanson SR, Kishikawa K, Wang SK, Sawa M, Wong CH Proc Natl Acad Sci U S A. (2007)

Sugar-assisted ligation in glycoprotein synthesis.

Yang YY, Ficht S, Brik A, Wong CH J Am Chem Soc. (2007)

Sugar-Assisted Glycopeptide Ligation.

Brik A, Yang YY, Ficht S, Wong CH J Am Chem Soc. (2006)