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Dr. Chi-Huey Wong
Joint Appointment Distinguished Research Fellow & President of Academia Sinica
Institute of Biological Chemistry, Academia Sinica
128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan
TEL: +886-2-2789-9400
FAX: +886-2-2785-3852
chwong@gate.sinica.edu.tw
Chi-Huey Wong's Website


Chemical Biology and Drug Discovery

Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of small molecules targeting proteins and RNA has been performed to investigate how small molecules interact with biologically important molecules and in turn, learn more about the function of those molecules. Development of both synthetic and bioorganic strategies is also paramount to our research. Programmable one-pot reactions are being developed for the synthesis of complex oligosaccharides and glycoarrays and compliment new chemo-enzymatic strategies for the assembly of glycoproteins and other biologically active molecules.

- 1982 Ph.D, Chemistry, Massachusetts Institute of Technology

2006 - present President, Academia Sinica, Taipei, Taiwan
2003 - 2006 Director, The Genomic Research Center, Acadmia Sinica, Taipei, Taiwan
1991 - 1999 Head, Frontier Research Program on Glycotechnolgy, Institute of Physical and Chemical Research (RIKEN), Japan
1989 - 2006 Professor and Ernest W. Hahn Chair in Chemistry, The ScripScripps Research Institute
1983 - 1989 Assistant Professor through Professor of Chemistry and Biochemistry, Texas A&M University
1982 - 1983 Postdoctoral Fellow, Harvard University

    Publications List
An Azido-BODIPY Probe for Glycosylation: Initiation of Strong Fluorescence Upon Triazole Formation.
Shie JJ, Liu YC, Lee YM, Lim C, Fang JM, Wong CH. J. Am. Chem. Soc. (2014)
Vaccination of Monoglycosylated Hemagglutinin Induces Cross-Strain Protection against Influenza Virus Infections.
Chen JR, Yu YH, Tseng YC, Chiang WL, Chiang MF, Ko YA, Chiu YK, Ma SH, Wu CY, Jan JT, Lin KI, Ma C. and Wong CH. Proc. Nat. Acad. Sci. U.S.A. (2014)
A new continuous fluorometric assay for bacterial transglycosylase using Förster resonance energy transfer.
Huang SH, Wu WS, , Huang LY, , Huang WF, , Fu WC, Yang ST, Chen PT, Fang JM, Cheng WC, Cheng TJR, Wong CH. J. Am. Chem. Soc. (2013)
Effective Sugar Nucleotide Regeneration for the Large-scale Enzymatic Synthesis of Globo H and SSEA4.
Tsai TI, Lee HY, Chang SH, Wang CH, Tu YC, Lin YC, Hwang DR, Wu CY, Wong CH. J. Am. Chem. Soc. (2013)
Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer.
Huang YL, Hung JT, Cheung SKC, Lee HY, Chu KC, Li ST, Lin YC, Ren CT, Cheng TJR, Hsu TL, Yu AL, Wu CY, Wong CH. Proc. Natl. Acad. Sci. U.S.A. (2013)
Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog and elucidation of the mechanism of peptidoglycan synthesis.
Huang CY, Shih HW, Lin LY, Tien YW, Cheng TJR, Cheng WC, Wong CH, and Ma C. Proc. Nat. Acad. Sci. U.S.A. (2012)
Enzymes in the Synthesis of Glycoconjugates.
Schmaltz, R.; Hanson, S.R.; Wong, C.H. Chemical Reviews (2011)
Toward Automatic Oligosaccharide Synthesis and Applications.
Hsu, C.H.; Hung, S.C.; Wu, C.Y.; Wong, C.H. Angew. Chem. Int. Ed. (2011)
Toward automated synthesis of oligosaccharides and glycoproteins.
Sears P, Wong CH. Science (2001)
Enzymes for chemical synthesis.
Koeller KM, Wong CH. Nature (2001)

Updated 2014.08.25

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