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梁博煌 博士
研究員
臺灣大學生化科學研究所 309室
臺北市106羅斯福路四段1號
TEL: +886-2-2366-5539
FAX: +886-2-2363-5038
phliang@gate.sinica.edu.tw

(i) 酵素反應機制,結構及根據重要酵素作藥物研發,包括undecaprenyl pyrophosphate synthase, octaprenyl pyrophosphate synthase, geranylgeranyl pyrophosphate synthase, 3CL proteases from SARS coronavirus, enterovirus 71, coxsackie virus, and neuraminidase from avian influenza virus (ii) 細胞凋亡機理及抗癌藥物研發. (iii) 生物高分子的合成及分解酵素研究包括rubber prenyltransferase, hyaluronan synthase. endo, exo-, and beta-glucosidases for cellulose degradation and biofuel production.

1989 - 1994 博士, 化學暨生化系, 美國馬里蘭大學
1982 - 1986 學士, 化學系, 臺灣大學。

2010 - present 理事, 亞太蛋白質學會
2009 - present 理事, 臺灣生物化學及分子生物學學會
2007 - present 編輯委員, Bioorganic Chemistry (Elsevier) and JCCS
2006,11 - present 研究員, 中研院生化所
2008 - 2010 共同主持人, 蛋白生產及X光結構分析核心設施
2006,12 - 2011,08 副所長, 中研院生化所
2005,05 - 2008,04 主持人, 重組蛋白生產核心設施
2004,07 - 2011,12 Chem Biology & Mol Biophys 召集人, 中研院國際研究生學程
2004,07 - 2007,06 祕書長, 2007-迄今 理事, 中華民國生物物理學會
2003 - 2007 合聘副教授, 2007-迄今 教授, 臺大生命科學院生化所
2002,11 - 2006,10 副研究員, 中研院生化所
1999,03 - 2002,10 助研究員, 中研院生化所
1996,10 - 1999,02 研究員, 史克美占藥廠巨分子科學及蛋白質化學系
1995,07 - 1996,09 助理研究員, 美國耶魯大學醫學院藥學系
1994,05 - 1995,06 博士後研究員, 美國耶魯大學醫學院藥學系

    論文列表
Identification, synthesis and evaluation of new neuraminidase inhibitors.
Kumar V, Chang CK, Tan KP, Jung YS, Chen SH, Cheng, YS, Liang PH Organic Letters (2014)
Control activity of yeast geranylgeranyl diphosphate synthase from dimer interface through H-bonds and hydrophobic interaction.
Chang CK, Teng KH, Lin SW, Chang TH, Liang PH Biochemistry (2013)
Moiety-linkage map reveals selective non-bisphosphonate inhibitors of human geranylgeranyl diphosphate synthase.
Chen SH, Lin SW, Lin SR, Liang PH, Yang JM J. Chemical Information & Modeling (2013)
Targeting the XIAP/caspase-7 complex selectively kills caspase-3 deficient malignancies.
Lin, Y. F. Lai, T. C., Chang, C. K., Chen, C.L., Huang, M.S., Yang, C.J., Liu, H. G., Dong, J. J., Chou, Y.A., Teng, K. H., Chen, S. H., Tian, W. T., Jan, Y. H., Hsiao, M., and Liang, P. H. J. Clinical Investigation (2013)
Structure of the catalytic domain of the Clostridium thermocellum cellulase CelT.
Kesavulu MM, Tsai JY, Lee HL, Liang PH, Hsiao CD Acta Cryst. D. (2012)
Targeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca2+ entry, mitochondrial perturbation and caspase overactivation
Lin YF, Lee YF, Liang PH Cell Death & Disease (2012)
Construction and characterization of different fusion proteins between cellulases and β-glucosidase to improve glucose production and thermostability.
Lee HL, Chang CK, Teng KH, Liang PH BIORESOURCE TECHNOLOGY (2011)
Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery.
R. Ramajayam, Kian-Pin Tan, Po-Huang Liang BIOCHEMICAL SOCIETY TRANSACTIONS (2011)
Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthase.
Chia-Hsiang Lo, Ying-Hsuan Chang, Jon D. Wright, Shih-Hsun Chen, Daphne Kan, Carmay Lim, and Po-Huang Liang Journal of the American Chemical Society (2009)
Intracellular beta-tubulin/Chaperonin containing TCP1-beta complex serves as a novel chemotherapeutic target against drug-resistant tumors.
Yuan-Feng Lin, Wen-Ping Tsai, Hon-Ge Liu, and Po-Huang Liang Cancer Research (2009)

Updated 2015.10.19

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