Molecular architecture of PTPN3-p38γ complex sheds light on structure-based drug design to antagonize Ras transformation

Ras signaling cascade has long been considered as an attractive therapeutic target for ... Read more

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Rules are Made to be Broken: How a Viral DNA Polymerase Breaks the Golden Watson-Crick Rule

Replication of DNA occurs in all living organisms and forms the basis of biological inheritance ... Read more

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Molecular Evidence to Show How Autophagy Serves as a Protective Mechanism against Oxidative Stress

Research team led by Dr. Guang-Chao Chen used fruit fly (Drosophila) adult midgut and ... Read more

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Revealing Structural Changes of Prion Protein during Conversion from α-Helical Monomer to β-Oligomers by Means of ESR and Nanochannel Encapsulation

Yang C, Lo WL, Kuo YH, Sang JC, Lee CY, Chiang YW, Chen RP ACS chemical biology [Epub ahead of print] (2014)

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Effects of single N-glycosylation site knockout on folding and defibrinogenating activities of acutobin recombinants from HEK293T

Inn-Ho Tsai, Ying-Ming Wang, Kai-Fa Huang Toxicon, 94:50-59 (2015)

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Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation

Kao C, Chao A, Tsai CL, Chuang WC, Huang WP, Chen GC, Lin CY, Wang TH, Wang HS, Lai CH Cell Death & Disease [Epub ahead of print] (2014)

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