Molecular architecture of PTPN3-p38γ complex sheds light on structure-based drug design to antagonize Ras transformation

Ras signaling cascade has long been considered as an attractive therapeutic target for ... Read more

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Rules are Made to be Broken: How a Viral DNA Polymerase Breaks the Golden Watson-Crick Rule

Replication of DNA occurs in all living organisms and forms the basis of biological inheritance ... Read more

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Molecular Evidence to Show How Autophagy Serves as a Protective Mechanism against Oxidative Stress

Research team led by Dr. Guang-Chao Chen used fruit fly (Drosophila) adult midgut and ... Read more

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Glutathionylspermidine in the Modification of Protein SH Groups: The Enzymology and Its Application to Study Protein Glutathionylation

Lin JC, Chiang BY, Chou CC, Chen TC, Chen YJ, Chen YJ, Lin CH Molecules, 20(1):1452-1474 (2015)

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Characteristic tandem mass spectral features under various collision chemistries for site-specific identification of protein s-glutathionylation

Chou CC, Chiang BY, Lin JC, Pan KT, Lin CH, Khoo KH Journal of the American Society for Mass Spectrometry, 26(1):120-132 (2015)

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Avenaciolides: Potential MurA-Targeted Inhibitors Against Peptidoglycan Biosynthesis in Methicillin-Resistant Staphylococcus aureus (MRSA)

Chang CM, Chern J, Chen MY, Huang KF, Chen CH, Yang YL, Wu SH Journal of the American Chemical Society, 137(1):267-275 (2015)

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